Itilima District is one of the five districts of Simiyu Region of Tanzania, East Africa.

[1][2] Itilima was established in 2012, when it was split off from Bariadi District and became part of the newly established Simiyu Region.

[3] The highway that connects Shinyanga Region and Mara Region (trunk road T36)[4] passes through Itilima district from south to north.

[5] The east of Itilima District is part of Maswa Game Reserve.

[6] As of 2012, Itilima District was administratively divided into 22 wards.