He played college football for the Samford Bulldogs and was selected by the Carolina Panthers in the second round of the 2016 NFL draft.

[2] Rated a two-star recruiting prospect,[6] Upon graduating from Pleasant Grove in 2010, Bradberry enrolled at Arkansas State University on June 30, 2011.

Bradberry returned to start in 12 of the 13 games of the 2013 season in which he totaled 26 tackles, 17 solo stops, two interceptions 10 pass break-ups.

[11] Defensive coordinator Sean McDermott held a competition during training camp to name a new starting cornerback after the Panthers released Josh Norman.

[15] On October 2, 2016, he made two solo tackles before exiting the Panthers' 48–33 loss at the Atlanta Falcons in the second quarter with an injury.

Bené Benwikere and fellow rookie Daryl Worley, who replaced Bradberry, gave up over 300 receiving yards to Julio Jones.

[18][19] Bradberry was inactive for the next three games (Weeks 5–8) due to a severe case of turf toe he sustained during the loss to the Falcons.

[21] On January 1, 2017, Bradberry made six solo tackles, two pass deflections, and intercepted Jameis Winston during a 17–16 loss at the Tampa Bay Buccaneers.

[27] On October 12, 2017, Bradberry recorded six combined tackles, broke up a pass, and made his first career sacks on quarterback Carson Wentz during a 28–23 loss to the Philadelphia Eagles.

[30] Bradberry finished the 2017 season with 85 combined tackles (66 solo), ten pass deflections, three interceptions, and a sack in 16 games and 16 starts.

[31] The Panthers finished second in the National Football Conference (NFC) South with an 11–5 record and received a Wild Card berth.

[32] On January 7, 2018, Bradberry started in his first career playoff game and recorded seven combined tackles as the Panthers lost 31–26 at the New Orleans Saints in the NFC Wild Card Round.

[36] In Week 6 against the Buccaneers, Bradberry recorded a team high ten tackles and made two interceptions off Jameis Winston in the 37–26 win.

[39] In Week 2 against the Chicago Bears, Bradberry recorded his first interception as a Giant off a pass thrown by Mitchell Trubisky during the 17–13 loss.

[41] In Week 7, Bradberry recorded his third interception on the season from Carson Wentz in a 22–21 loss to the Eagles on Thursday Night Football.

[55] The penalty proved costly for the Eagles as Harrison Butker kicked a game-winning field goal with 11 seconds left leading to the Chiefs' 38–35 win.