Shetty has often said that he spent three years, from 2010 to 2013, living the ISKCON lifestyle at an undisclosed ashram in Mumbai, India,[11][12][13] but his own blog posts and people familiar with his movements in that period indicate he spent most of this time making promotional videos at Bhaktivedanta Manor in Watford,[10] with Shetty writing in a blog post that he had arrived in India in October 2010 and had spent less than four months in the country before leaving again.

[6] Shetty began his career at Accenture, working on digital strategy and as a social media coach for the company's executives.

[14][16][9][17] Shetty stopped working for the HuffPost in early 2017, later releasing videos independently on Facebook and YouTube.

[22][23] In July 2023, Shetty interviewed US President Joe Biden on his mental health initiatives in a podcast episode filmed at the White House.

[26][27][28] Shetty is the co-founder of a video production company, Icon Media, along with Alex Kushneir.

[29][14] In 2021, Shetty and his wife Radhi launched Sama Tea, an adaptogenic brand inspired by ayurveda.

It claims to provide a Level 7 diploma, which is equivalent to a Master's degree in the United Kingdom.

The book offers advice on reducing stress and improving focus, based on Shetty's experiences from living at an ashram.