Jervine is a steroidal alkaloid with molecular formula C27H39NO3 which is derived from the plant genus Veratrum.

Similar to cyclopamine, which also occurs in the genus Veratrum, it is a teratogen implicated in birth defects when consumed by animals during a certain period of their gestation.

[citation needed] Jervine is a potent teratogen causing birth defects in vertebrates.

[citation needed] Jervine's biological activity is mediated via its interaction with the 7 pass trans membrane protein smoothened.

Jervine binds with and inhibits smoothened, which is an integral part of the hedgehog signaling pathways.