Incumbent Democratic Senator Michael Bennet won reelection to a third term, defeating the Republican candidate, businessman Joe O'Dea.

Due to some of his centrist positions, such as his opposition to Medicare for All and his support for fracking, Bennet faced a potential challenge from the left, particularly from Joe Salazar, a former state representative.

[4] Executive branch officials U.S. senators U.S. governors U.S. representatives State legislators Organizations Initially, a wide field of candidates declared their intention to seek the Republican nomination.

[23] Though O'Dea was initially considered the frontrunner as a result of his fundraising advantage, Hanks was buoyed by an attempt by Democrats to influence the primary.

Prevailing in 2010, a year where Colorado was considered a swing state and Democrats performed very poorly, Bennet had a generally strong electoral history.

Ahead of 2022, Bennet was generally favored to win, though polling showed him as potentially vulnerable, largely due to the state of the economy and President Biden's low approval ratings.

Bennet ultimately won reelection by a comfortable 14.6 point margin, outperforming Biden's victory two years prior and his own polling averages.