It is produced by Natural Alternatives International of San Marcos, California, for National Safety Associates (NSA; Collierville, Tennessee).

[10] In 1993, the United States Attorney General's office followed up on complaints that the company was deceptively requiring new distributors to make large upfront purchases of air and water filters.

[19] Two NAI-sponsored studies [20] mention that the fruit and vegetable powders in Juice Plus include standardized levels of natural β-carotene derived from Dunaliella salina and soy-derived d-α-tocopherol (vitamin E), which are supplied by the Henkel Corporation (now doing business as Cognis Corporation),[21][22] and ascorbic acid derived from acerola cherry, which is supplied by Schweizerhall Pharma.

Testing included amounts of selected index elements, their ability to disintegrate in solution per United States Pharmacopeia guidelines, lead contamination threshold set in California Proposition 65, and meeting U.S. Food and Drug Administration (FDA) labeling requirements.

[24] Garden Blend failed ConsumerLab's test as it contained only 76.4% of its claimed calcium, which was noted was low to start (labeled as just 4% of the Daily Value per serving.)

On 23 June 2011, ConsumerLab was informed of misinformation circulated by a Juice Plus distributor incorrectly stating the variation was due to the analytical method used.

[4][5][6][30][33][35] Memorial Sloan-Kettering Cancer Clinic referred to Juice Plus as a "pricey supplement" that is "distributed through a multi-tiered marketing scheme with exaggerated value and cost.

[37][38] In a critique of Juice Plus,[4] consumer health advocate and alternative medicine critic Stephen Barrett of MLM Watch remarked upon the previous association between two authors of a 1996 Juice Plus research study [20] and United Sciences of America, Inc. (USAI), a multilevel marketing company that sold vitamin supplements with illegal claims that they could prevent many diseases.

The AGCM cited evidence that the companies were posting fake user testimonials alleging that the products could help with weight loss and disease treatment.

[47][48][49] In February 2020, the company that markets Juice Plus in Australia was hit with a $37,800 penalty by the Australian Therapeutic Goods Administration (TGA) subsequent to the issuance of three infringement notices relating to the promotion of Juice Plus vitamin products for medical conditions, and to the use of endorsements by health professionals, in violation of the Therapeutic Goods Advertising Code.

[51] University of California Berkeley Wellness Letter[31] and MLMWatch[4] commented on the unreliability of Juice Plus testimonials provided by former professional athlete O. J. Simpson.

In March 1994, Simpson was videotaped telling 4,000 Juice Plus distributors at a sales meeting that the product had cured his arthritis, improved his golf game, and freed him from using anti-arthritic drugs.

In fiscal year 2007, the majority of funds donated to the foundation were disbursed to Volunteers of America (a faith-based social welfare organization) and to the Boys & Girls Clubs of Memphis.

The University of California Berkeley Wellness Letter and Stephen Barrett of MLM Watch questioned the survey's scientific value, and claimed that the Foundation is being used mainly as a marketing gimmick to get families to buy Juice Plus products.