[3] Throughout the day the on-air programmers who could be heard on KWIX include, Brad Boyer, Bill Peterson, Brad Tregnago, Aaron Wood, Eric Messersmith, Brian Hauswirth, Matt Tarnawa, Matt Elliott, Brennan Holtzclaw, Dan Patterson and Curt Derr.

In the early 1990s, KWIX-KRES radio's on-air staff included St. Louis-area transplants such as Bryan Polcyn, Doug Stewart, Mike Roberts and Paul Lewandowski.

The original KWIX was a shortwave radio station based in San Francisco, California, commissioned by the federal government in World War II.

On March 1, 2007, it was announced that GoodRadio.TV LLC plans to buy The Shepherd Group of radio stations in Missouri.

The Shepherd Group includes KJEL and KBNN in Lebanon; KJFF in Festus; KREI and KTJJ in Farmington; KRES and KWIX in Moberly; KIRK in Macon; KOZQ-FM, KJPW and KFBD-FM in Waynesville; KAAN-FM and KAAN-AM in Bethany; and KMRN and KKWK in Cameron.