KCC was founded in 1924 by representatives of 40 local chambers of commerce, who met in Hutchinson, Kansas.

[1] The chamber created a number of committees in 1930: agriculture; industry; tourist travel; advertising and publicity; research and conservation; forestation and recreation; and education.

[1] The Kansas Chamber of Commerce "is to continually strive to improve the economic climate for the benefit of every business and citizen and to safeguard our system of free, competitive enterprise.

"[2] The chamber says it aims to represent the interests of small, medium, and large employers from all industry sectors.

It strives to build meaningful coalitions and collaborative partnerships that influence Kansas legislation, according to the organization.