[4] Predominantly settled by Iraqw, Karatu district is home to the hunter-gatherer community of the Hadza people.

Northern Karatu district is very fertile due to the many streams and volcanic soil from the Ngorongoro highlands.

Zone of the Highlands are: Lositete, Upper Kitete, Slahhamo, Kambi ya Simba, Kilimatembo, Rhotia Kati, Kainam Rhotia, Ayalabe, Tloma, Oldeani, Getamock, Buger, Ayalalio, Endonyawe, and Makhoromba are all included.

[11] Locations such as; Chemchem, Kilimamoja, Gyekrum Lambo, Gyekrum Arusha, Gongali, Bashay Qurus, Endashangwet, Changarawe, Bassodawish, Endamarariek, Khusmayi, Endallah, Qaru, Endabash, Kambi ya Faru, Laja, and Ngaibara are all part of the Midlands Zone.

[12] The lowlands includes Matala, Dumbechand, Jobaj, Mbuga Nyekundu, Qangdend, Endamaghan, Maleckchand, Mang'ola Barazani, and Laghangarer.

Some people work in retail establishments in Manyara and Karatu towns, as well as Endabash, Oldeani, and Mang'ola commercial centers.

Vodacom, Tigo, Zain, and Zantel operate 548 telephone lines (TTCL) and a cellular network.

[15] Paved trunk road T17 from Arusha to the Ngorongoro National Park passes through the district.

Other important indicators of development include the following: literacy rate of 64%, population growth rate of 3.1, dependency ratio of 97, employment in agriculture 61%, livestock keeping 7.49%, office 3.14%, elementary occupation 21.33%, plant operations/assemble 0.37%, business operation 3%, hand hoes owned by 79% of the population, sex ratio of 108, energy consumption (electricity) is 4%, and firewood is 96%.

[18] Farmers in the district are advanced in agriculture since 65% of them utilize hybrid seeds, artificial fertilizers, and tractors in farm preparation.

Small-scale enterprises primarily process farm goods, however others employ other inputs such as coffee.

[21] As of 2016, a significant number of Karatu residents are involved in trading, with over 2,000 trading entities in operation, ranging from retail and wholesale shops to hospitality industries such as kiosks, restaurants, and hotels; apartments, boarding houses, lodging, and guest houses, as well as liquors bars; transport business; banking; bookshops, stationeries, and printing; beauty salon and barber shops; professional consultancies; farm implements; butchers; pharmacies and mobile phones retailers.

[22] Endoro waterfalls, Lake Eyasi, Kambi ya simba Forest Reserve, Mount Oldeani, Mumba rock paintings, and Yaeda Valley for cultural tourism to see the Hadzabe and Datooga communities are some of the important attractions in Karatu district.