Dr. Karl Malus appeared in the second season of the Marvel Cinematic Universe television series Jessica Jones, portrayed by Callum Keith Rennie.

Malus offers to cure Spider-Woman's friend Scotty McDowell, who was rendered comatose by one of the Enforcer's poison bullets, in exchange for leniency.

[7] Malus later works for the Power Broker (Curtiss Jackson), using his technology to augment the strength of paying customers to superhuman levels.

[8] When Power Broker, Inc. is attacked by the Scourge of the Underworld, Curtiss Jackson is exposed to his own augmentation device and rendered overly muscular and immobile.

He uses an explosive wristband to force Vagabond's cooperation, but she manages to knock Malus out, destroy the fingerprint mold, place the band on his wrist, and inject him with the drug he had planned to use on her.

Malus captures and experiments on several augmented individuals to perfect the de-augmentation process, including Battlestar, which draws the attention of the U.S.

[volume & issue needed] He also worked with the Avengers and the Thunderbolts in their efforts to defeat Count Nefaria in exchange for a reduced sentence.

[15] Malus returns in "All-New, All-Different Marvel", having survived, become a symbiote hybrid, and continued his experimentation as an employee of Serpent Solutions.

Years prior, when Jessica Jones and her mother Alisa are critically injured in a car accident, Malus arranged for them to be transferred to his clinic so he could save them.

Over the course of treating her, Malus developed romantic feelings for Alisa, going so far as to cover up her accidentally killing of one of his nurses by framing a janitor for it and eventually marrying her.

When Trish Walker begins investigating IGH in the present, Malus allows Alisa to murder the clinic's subjects and associates.

[18][19] Malus and Jessica get into an argument, with the former claiming he truly loves Alisa despite her condition before fleeing after the mother and daughter argue and fight.