Pickett won Super Bowl LIX with the Eagles, entering the game in the final moments to close out the victory over the Kansas City Chiefs.

Pickett led the Ocean Township Spartans to the New Jersey Central Group III semifinal game as a junior, leading his team to a 9–2 record.

[4] Pickett spent most of his true freshman season at Pittsburgh in 2017 as a backup to Max Browne and Ben DiNucci.

[10] Pickett led Pittsburgh to their first ever Atlantic Coast Conference Coastal Division Championship in his first season as the full-time starter.

[17] The NCAA granted all 2020 fall athletes an extra year of eligibility, and Pickett used this option to return as the Panthers' starting quarterback in 2021.

[22] Various journalists scrutinized Pickett prior to the draft for his relatively small hands, measured at 8½ inches, believing it could make him more prone to fumbling the ball.

[32] Pickett made his NFL debut in the second half of a Week 4 loss against the New York Jets after Trubisky was benched.

On his first career pass attempt, Pickett threw a deep ball to Chase Claypool that was intercepted by Jordan Whitehead.

[36] In Week 6 against the Tampa Bay Buccaneers, Pickett threw his first touchdown pass to Najee Harris, but he exited the game during the third quarter with a concussion.

[42] In Week 17 against the Baltimore Ravens, Pickett threw a game-winning touchdown with under a minute left for the second consecutive game; a 10-yard pass to Najee Harris.

[43] Pickett became the first rookie quarterback in NFL history to throw a game-winning touchdown in the final minute of the fourth quarter in two straight games.

[45] On March 13, 2023, the game ball from the Steelers' victory over the Las Vegas Raiders was put on display in the Professional Football Hall of Fame.

[46] A week later, he went 15 of 23 for 114 yards and an interception before sustaining a bone bruise late in the third quarter during their 30–6 road loss to the Texans.

[47] During the team's 24–17 road victory over the Rams in Week 7, Pickett scored his first rushing touchdown of the season on a quarterback sneak.

[48] In Week 8, during a 20–10 home loss to the Jaguars, Pickett suffered a rib injury late in the second quarter and did not return.

However, Pickett started four days later against the Titans, leading the team to a 20–16 victory with a game-winning touchdown pass in the fourth quarter.

[54] Pickett entered the season as the backup quarterback behind incumbent starter Jalen Hurts, despite a competition with Tanner McKee.

[56] On November 10, during a blowout 34–6 victory over the Dallas Cowboys, Pickett would relieve Hurts, completing one of two attempts for five yards.