The highway travels through mostly rural areas of Taylor and Marion counties.

KY 208 begins at an intersection with US 68/KY 55 (New Lebanon Road) west of Spurlington, within Taylor County.

KY 208 travels to the north-northeast and enters Marion County.

It crosses over Pontchartrain Creek, passes Calvary Elementary School, and curves to the north.

It crosses over Indian Lick Creek and meets its northern terminus, an intersection with KY 2154 (Veterans Memorial Highway), where the roadway continues into Lebanon as New Calvary Road.