They are expressed in single layer epithelial tissues of the body.

Mutations in this gene have been linked to cryptogenic cirrhosis.

Two transcript variants encoding the same protein have been found for this gene.

[6] Keratin 18 has been shown to interact with Collagen, type XVII, alpha 1,[7] DNAJB6,[8] Pinin[9] and TRADD.

This article on a gene on human chromosome 12 is a stub.