Kuprian Osipovich Kirkizh (Russian: Куприян Осипович Киркиж; 29 September 1886 – 24 May 1932) was a Belarusian revolutionary and Soviet statesman who served as the second General Secretary of the Communist Party of the Uzbek SSR from 1927 until April 1929.

He was initially a member of the Vitebsk Committee of the RSDLP (b) and he was active in underground party work in Riga.

From 1922 to 1925 he was executive secretary of the Kharkiv Provincial Committee of the Communist Party of Byelorussia (b).

From November 1926 to February 1927 he was People's Commissar of the Workers 'and Peasants' Inspectorate of the USSR and Chairman of the Central Control Commission of the Communist Party of Ukraine.

[2] After a visit to the Kovrov Tool Plant on May 21, 1932, Kirkizh's car crashed on the way back to Moscow and he as well as the other passengers were severely injured and were taken to a hospital in Vladimir for treatment.