L-Ribonucleic acid aptamer

The affinity of L-RNA aptamers to their target molecules often lies in the pico to nanomolar range and is thus comparable to antibodies.

[4] They are excreted by the kidneys in a short time due to their low molar mass (which is below the renal threshold).

Unlike other aptamers, L-RNA aptamers are not directly made using systematic evolution of ligands by exponential enrichment (SELEX), as L-nucleic acids are not amenable to enzymatic methods, such as polymerase chain reaction (PCR), used in SELEX.

[4] Conventional (up to 1016 different oligonucleotides) existing molecule library serves as a starting point for the subsequent SELEX process.

[clarification needed] Selection, separation, and amplification using the mirror image of the target molecule is performed.