[7] It resides primarily across lysosomal membranes,[8] and functions to provide selectins with carbohydrate ligands.

[8] The extracytoplasmic region contains a hinge-like structure which can form disulphide bridges homologous to those observed in human immunoglobulin A.

[16][17] The structure of LAMP1 correlates with differentiation[8][20] and metastatic potential[11] of tumor cells as it is thought to help mediate cell-cell adhesion [17] and migration.

[15][18] Indeed, the adhesion of some cancer cells to the extracellular matrix is mediated by interactions between LAMP1 and LAMP2 and E-selectin and galectins, with the LAMPs serving as ligands for the cell-adhesion molecules.

[17] Cell membrane expression of LAMP-1 observed in the following cancer types: This article incorporates text from the United States National Library of Medicine, which is in the public domain.