The function of LILRA3 is currently unknown; however, it is highly homologous to other LILR genes,[2] and can bind human leukocyte antigen (HLA) class I.

Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.

[3][4][5] Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles [6]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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