[1] They are also known as CD85, ILTs and LIR, and can exert immunomodulatory effects on a wide range of immune cells.
The LILR family is a cluster of paired receptors with both activating and inhibitory functions.
[3] Of these, the inhibitory receptors LILRB1 and LILRB2 show a broad specificity for classical and non-classical MHC alleles with preferential binding to b2m-associated complexes.
In contrast, the activating receptors LILRA1 and LILRA3 prefer b2m-independent free heavy chains of MHC class I, and in particular HLA-C alleles.
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