Lady Dimitrescu's physical design was based on Polish model Helena Mankowska, while her voice acting and motion capture were performed by American theatre actress Maggie Robertson.

Following initial previews of Village, Lady Dimitrescu rose in popularity and has become the subject of a significant amount of fan-driven labor, including fan art, cosplay, memes, and erotica.

Journalists and commentators took note of the trend, which began before the release of Village in May 2021, attributing the rapid surge of fan interest in the character to aspects of her appearance and her sex appeal.

[12][13] According to Tomonori Takano, the art director for Resident Evil Village, the development team intended to move away from using simplistic elements like zombies to scare players and instead focus on creating unique situations and memorable characters who would create fear in new ways, continuing a trend that began in Resident Evil 7: Biohazard, the predecessor to Village.

They are products of her experiments with the Cadou parasite whose bodies are composed of imitation flies that aggregate into the forms of the corpses they devour and can thrive only within the castle's walls.

In the aftermath of World War II and the abolition of the nobility, Dimitrescu returned to her family's former lands, which had fallen under the control of a neopagan cult worshipping the Black God.

Dimitrescu suffered a hereditary blood disease prior to meeting Miranda, who infected her with the Cadou parasite to see if she was compatible with her plans to revive her daughter.

This control allowed Dimitrescu's family to rule her castle with barbarous cruelty, regularly taking in new staff to replace those who were taken to the dungeon to be killed; their blood was used to create an enriched red wine.

[25][26] In the downloadable content expansion "The Mercenaries: Additional Orders" for Resident Evil Village released in October 2022, Lady Dimitrescu is one of the playable characters.

[39] Lady Dimitrescu received very positive reception from critics and players following her initial reveal in a 2020 promotional trailer for Resident Evil Village and her appearance in the 2021 PlayStation 5–exclusive demo Maiden.

[41][42][43] Even though Village was scheduled for launch on May 7, 2021, Dimitrescu's surge in popularity in early 2021 led to a significant proliferation of fan exploration of the character through fan art,[44][45] including a fan-made action-figure commercial,[46][47] cosplay activities by notable individuals including Han and Olympic bronze medalist Yekaterina Lisina,[48] and internet memes, which sometimes involved participation by other video game developers on social media.

[51][52] In March 2021, Epic Games distributed a survey to Fortnite players in order to gauge interest in future crossover promotions; the list of potential characters and brands included Lady Dimitrescu, Jill Valentine, and Ethan Winters.

[54][55] Several commentators discussed at length the reasons behind the character's popularity, with many identifying her unusually tall height as a key element drawing fan interest.

[41][42][18][56][19] Leon Hurley of GamesRadar+ observed that Dimitrescu was not the main villain of Village or its most important character, but nevertheless had become more prominent, popular, discussed, and imitated than was originally intended or expected.

[58] In December 2021, Ed Nightingale of Eurogamer described her as the "most memorable character of the year", saying that "Lady Dimitrescu embodies all of this, straddling the line between horror, sex, and camp.