Because of Peter Jackson's adaptation popularity during the game's development, artist Masaki Yamanaka created and designed Luis to look like J. R. R. Tolkien's Aragorn from The Lord of the Rings.

According to Yamanaka, Peter Jackson's adaptations were still popular during the development of Resident Evil 4, and as such, he wanted Luis to resemble Aragorn from J. R. R. Tolkien's The Lord of the Rings to rival protagonist Leon S. Kennedy as "the game's hottest man.

[15] However, post-launch critics praised the remake for its depiction of Luis: Jade King of TheGamer described him as a "fan favorite" and "unexpected star" of the game.

According to Beahm, he is the perfect example of a "great ally NPC" who saves certain situations in the remake with his sheer personality, ensuring you have something to look forward to between "Leon's stiff-faced trumping".

[17] In academic analysis, scholar Adriana Falqueto Lemos argued that Luis Sera's exaggerated appearance, accent, and speech are all part of the fictional representation of what a Spanish guy can be, with nothing extraneous.

She further said that "there are ideological projects, even if unintended, that make certain ideas of the social and the real prevail through the manufacturing of video games, so why choose to portray a Spaniard in one way and not in another?

"[18] The construction of the non-playable characters is one example of how Resident Evil 4's "spatial and temporal diegetic inconsistency" is represented in its locations, according to scholar Andrei Nae.

As stated by Nae, Luis is a Madrid-based police officer and a skilled biologist who embodies the stereotypical Mexican of the nineteenth century in twentieth-century American Western films.