Originally designed for Resident Evil 7: Biohazard, it has since been used in a variety of the company's games, such as Devil May Cry 5, Monster Hunter Rise and Street Fighter 6.

Jun Takeuchi, the head of Capcom's Division 1 stated "we had to rethink the way we make games.

No single game or franchise drives the direction of the engine, according to Monster Hunter producer Ryozo Tsujimoto, and instead all studios contribute towards its improvement.

[12] When discussing Monster Hunter Rise, Yasunori Ichinose, the game's director, discussed porting RE Engine to the Nintendo Switch, and said "a lot of background technical engineering work need[ed] to be done just to achieve targeting a new hardware platform", and mentioned the challenge of creating the large maps the team wanted while trying to maintain the game's graphical quality.

It also includes improved VR support over its predecessor, allowing it to hit high framerates necessary to avoid motion sickness.