Lancaster County is part of the Lincoln, NE Metropolitan Statistical Area.

In the Nebraska license plate system, Lancaster County was represented by the prefix 2 (it had the second-largest number of vehicles registered in the state when the license plate system was established in 1922).

In 2002, the state discontinued the 1922 system in Lancaster, Douglas and Sarpy counties.

Lancaster County is divided into the following census divisions called precincts, defined by the boundaries of the original townships,[21] except for the City of Lincoln.

In the last 30 national elections, Lancaster County selected the Republican Party candidate 78% of the time.

However, it has become more competitive in recent years, largely due to the influence of Lincoln and the University of Nebraska.

As of January 2025, Republicans maintain a relative advantage in party registration in the county.