[2] In the Nebraska license plate system, Saline County is represented by the prefix 22 (it had the twenty-second-largest number of vehicles registered in the state when the license plate system was established in 1922).

[5] The terrain of Saline County is composed of low rolling hills, sloping to the east-southeast.

The Big Blue River flows southward in the eastern part of the county.

The middle and southern parts of the county are drained by Swan Creek and Turkey Creek, which combine and discharge into Big Blue River at the county's east boundary line close to its SE corner.

Saline County was formerly strongly Democratic, voting Republican only four times between 1900 and 1968.

However, in 2016, the county swung to the right, and since that election has weighed in as more than 20 percentage points more Republican than the nation.