McPherson County is part of the North Platte, NE Micropolitan Statistical Area.

In the Nebraska license plate system, McPherson County is represented by the prefix 90 (it ranked 90th of 93 counties in the number of vehicles registered when the license plate system was established in 1922).

The terrain of McPherson County consists of low rolling hills sloping to the south-southeast.

[6] As of the 2000 United States Census,[13] there were 533 people, 202 households, and 157 families in the county.

In only two national elections since 1900 has the county selected the Democratic Party candidate (as of 2024).

In 2016, Democrat Hillary Clinton had the worst showing for a major party Presidential candidate in the county's history, tallying just 14 votes for only 4.9%.

In 2024, Democrat Kamala Harris performed even worse than Clinton, receiving only 12 votes or 4.2%.