[2] In the Nebraska license plate system, Perkins County is represented by the prefix 74 (it had the seventy-fourth-largest number of vehicles registered in the county when the license plate system was established in 1922).

It is believed to have been named for Charles E. Perkins, the president of the Chicago, Burlington and Quincy Railroad.

The county terrain consists of arid, low rolling hills.

The planar areas are used for agriculture, usually employing center pivot irrigation.

[7] As of the 2000 United States Census[15] there were 3,200 people, 1,275 households, and 893 families in the county.

In no national election since 1936 has the county selected the Democratic Party candidate (as of 2024).