Laurel Hill Creek is a 39.9-mile-long (64.2 km)[5] tributary of the Casselman River that is located in Somerset County, Pennsylvania, in the United States.

It is responsible for draining 126 square miles of the 576 square miles drained by the Casselman River.

[7] Laurel Hill Creek drains the east slope of Laurel Hill in the Laurel Highlands and flows to the appropriately named community of Confluence, where it joins the Casselman River a few yards above the Youghiogheny.

Laurel Hill Creek finally passes through Lower Turkeyfoot Township, with tributaries such as Cranberry Glade Run, May Run, and Licking Run joining it before it enters the Casselman River in Confluence, just before the Casselman River flows into the Youghiogheny River.

Laurel Hill Creek was listed at #7 on American Rivers' "Most Endangered Rivers" list for 2009.