Lead Run is a tributary of East Branch Fishing Creek in Sullivan County, Pennsylvania.

The stream has a low pH and poor water quality, although that could potentially be remedied.

[1] Lead Run joins East Branch Fishing Creek 4.12 miles (6.63 km) upstream of its mouth.

[4] The average alkaline deficiency of Lead Run is 19 pounds (8.6 kg) per day.

[4] The water quality of Lead Run is considered to be "severe", a rating worse than "very poor".

Road liming has been suggested as a method of making Lead Run more alkaline.

[1] The lower reaches of Lead Run lie over rock of the Catskill Formation.

[4] The Pennsylvania Department of Environmental Protection listed Lead Run as impaired in 2002.