Leela develops a mutation which causes her to sprout tentacles all over her body, and ends up at a genetic engineering facility owned by Mom's Friendly Robot Company.
Dr. Tenderman explains that due to a genetic condition, her body has begun a process called squidification, in which her limbs "will be gradually transformed into a slithering mass of tentacles."
At the market, a con artist buys the ship for two gigantic, magic beans that are supposedly a miracle cure for Leela's ailment.
While trying to escape from the lab, Fry, Leela, and Bender encounter a giant bound to an operating table connected to medical machinery.
Later, Mom drops by to thank Leela for helping her to "engineer the perfect bean", incorporating suction cups which prevent the stalks from collapsing under their own weight.
The episode ends with Fry and a cured Leela walking hand-in-hand through New New York City, which has been transformed into a jungle of giant beanstalks.
[1] Max Nicholson of IGN gave the episode a 7.7/10 "Good" rating, saying "This week's Futurama put a unique twist on the classic Jack and the Beanstalk fairytale.