In this episode, the crew get trapped aboard the Planet Express ship with a horrific alien creature.
The episode's title derives from Murder on the Orient Express and parodies Alien and The Thing.
Hermes' video to spy on Zoidberg instead reveals that Bender had used his lunchbox to keep Fry's kidney on ice, which Leela unwittingly ate, much to everyone's disgust.
Frustrated at the crew's uncontrollable bickering, Farnsworth hires business consultant Dan McMasters to conduct a team building exercise.
Farnsworth splits the crew into three teams: Zoidberg and Hermes must restart the life support system, Leela and Amy must travel to the bridge to get the steering wheel so as to pilot the ship from the panic room, and Bender and Fry must relight the pilot light from outside the ship to get the engines restarted.
Fry then takes over Bender's body by wearing him like a suit, creating a combination dubbed "Frender", and gets him under control.
Amy's golf shot to the monster's face saves her and they make a run for the bridge and take the steering wheel.
McMasters assures them that the whole thing was staged to help build trust and the monster, Blorgulax, is his business associate.
He asks them to join him and the rest of the crew to a pizza party on the bridge, but Fry and Bender are convinced that he is the monster and kill him.