Originating at the north side of Arab Hill south of Delphi Falls, New York and northwest of DeRuyter Reservoir the creek begins traveling northward.

The upper reaches of the creek drain the valley of Pompey Hollow, west of Cazenovia Lake.

Downstream of there, it empties into Chittenango Creek which continues a few miles north to Oneida Lake.

The Edwards Falls, about 50 feet (15 m) high, are located on Limestone Creek near Manlius.

It is a three-span stone structure 79 feet (24 m) long, supporting a concrete aqueduct and the old towpath (now the Erie Canalway Trail).