The mayor is elected alongside city council every four years on the fourth Monday of October; there are no term limits.

The office is currently held by Carolyn Parrish, who assumed office on June 24, 2024, following her election in the by-election on June 10 to succeed former mayor Bonnie Crombie.

This list includes the two mayors of the Town of Mississauga (existing from 1968 to 1973), and the five mayors of the City of Mississauga (1974 to present): Before 1968, Mississauga was led by the reeves for the townships of Clarkson, Cooksville, Dixie, Erindale, Lakeview, Lorne Park, Malton, Meadowvale, Sheridan, and Toronto Township.

The City of Mississauga was formed with the merger of the towns of Mississauga, Port Credit and Streetsville: City councillor(s) may be appointed by the mayor on an honorary basis.

91% of polls reporting MacCallion ended up winning by a plurality of 54,158 votes.