This relatively unusual property, also called retrograde solubility, is shared with few inorganic compounds, such as calcium hydroxide (portlandite, an important mineral phase of hydrated cement paste), the calcium sulfates (gypsum, bassanite, and anhydrite) and lanthanoid sulfates whose dissolution reactions are also exothermic.

However, the exact energy of disassociation is difficult to quantify as it seems also to depend on the quantity (number of mols) of the salt added to water.

In common phase II form, Lithium sulfate has a sphenoidal monoclinic crystal system that has edge lengths of a = 8.23Å b = 4.95Å c = 8.47Å β = 107.98°.

When lithium sulfate is heated passed 130 °C it changes to a water free state but retains its crystal structure.

Transparent conducting film is a highly investigated topic as they are used in applications such as solar panels and the potential for a new class of battery.

Most of the current transparent ionic conducting films are made of organic plastics, and it would be ideal if an inexpensive stable inorganic glass could be developed.

[10][11] Feedstock of hard-rock spodumene concentrate is processed by acid roasting, followed by water leaching, achieving a lithium recovery of 84-88%.

Lithium sulfate has a rapid gastrointestinal absorption rate (within a few minutes), and complete following oral administration of tablets or the liquid form.

[12] For example, Li+ interacts with neurohormones, particularly the biogenic amines, serotonin (5-hydroxy tryptamine) and norepinephrine, which provides a probable mechanism for the beneficial effects in psychiatric disorders, e.g. manias.

Lithium sulfate is being used as a catalyst for the elimination reaction for transforming n-butyl bromide to 1-butene at close to 100% yields at a range of 320 °C to 370 °C.