The Free Trade International Bridge connects Los Indios with Matamoros, Tamaulipas.

Los Indios is likely named after a Spanish ranch and got its start in the year 1913, following construction of the San Benito and Rio Grande Valley Railway through that territory.

[7] According to the United States Census Bureau, the town has a total area of 1.7 square miles (4.4 km2), all land.

Frequently there will be an early morning line of 200 plus vehicles waiting to cross the border at Los Indios, bound for Central America.

The route through Mexico to the Guatemalan border at Ciudad Hidalgo is about 1,350 miles (2,170 km), virtually all two lane roads running through the centers of towns with heavy truck traffic during the day—a challenging journey even for an experienced transmigrante.

Los Indios is located in the San Benito Consolidated Independent School District.

The United States Postal Service operates the Los Indios Post Office along U.S. Highway 281.