[2][3] A settler of the area from around 1765, Derr purchased several tracts of land from the William Penn family and other neighboring landowners, the largest of which was known as "The Prescott".
Having been on the land for such a long time, Derr had befriended the local Native Americans of the area.
His relationship with these indigenous peoples was so well founded that, even as many of the other local settlers' homesteads were routinely sacked by Native Americans, Derr's lands remained free from attacks.
Subsequently, in 1784, he worked with Samuel Weiser to lay out his combined land tracts, and create Derrstown.
[6] After settling Lewisburg, Derr built a house and a mill near the West Branch Susquehanna River and Limestone Run.