It runs for around 1.6 miles (2.6 km), from Main Street, at the Union County/Northumberland County line, in the east to North Fairground Road in the west.

Lewisburg's street layout was designed by Ludwig Derr in 1785, and is believed to have been inspired by that of Philadelphia.

[1] The street is part of the Lewisburg Historic District,[2] which was added to the National Register of Historic Places in 2004.

The Packwood House-American Hotel (1813), the Chamberlin Iron Front Building (1868), Copper Beech Manor (1857) and the William Cameron Home (1887) are each on Market Street.

Throughout the nine blocks of the Historic Market Street Corridor, 115 of the 125 buildings are classified as being contributing structures to the historic character of the district.