Currently, as Associate Professor in biochemistry, he leads the laboratory of recombination and DNA repair (LORD) at the Department of Biology, Faculty of Medicine, at Masaryk University in Brno.
[5] His most cited papers are: Lumír Krejčí was born in Slavičín in the Zlín Region of the Czech Republic.
Throughout his career, Lumír Krejčí was mainly interested in understanding the mechanisms living organisms use to cope with genome instability, more precisely homologous recombination.
The main objectives of his lab’s research are “to decipher the intrinsic functions of homologous recombination (HR) which has a dual role in the maintenance of genome stability.
Moreover, HR is responsible for the creation of genetic variability during meiosis by directing the formation of reciprocal crossovers that result in random combinations of alleles and traits.”[2] His main contributions concerns: (i) the effect of post-translational modification of diverse HR proteins by Sumo protein (examples include: Rad52.,[8] Rad59,[9] PCNA[10]); (ii) elucidation of the molecular mechanism of the key step of HR, recombination-associated DNA synthesis;[11][12] (iii) role of paralogues of RAD51 in promoting RAD51 filament stability[3][4] Currently, the laboratory focuses on two main topics, development of novel active compounds targeting diverse nucleases and understanding the regulation of RAD51 nucleofilament.