At the northern portal, which is located at 51°24′12″N 9°42′31″E / 51.40333°N 9.70861°E / 51.40333; 9.70861, the trains cross the valley of the river Werra on the Werra Viaduct at Hedemünden, parallel to the A 7 autobahn.
At the southern portal, (51°21′45″N 9°34′33″E / 51.36250°N 9.57583°E / 51.36250; 9.57583) they cross the Ickelsbach valley, after which the Mühlenkopf Tunnel follows immediately.
There is an emergency exit about halfway through the tunnel, at km 127 (51°23′18″N 9°37′50″E / 51.38833°N 9.63056°E / 51.38833; 9.63056), which is accessible through a 15 metre deep staircase.
Due to ecological considerations, however, the line was lowered by 30 metres and the Wandersteinbach was crossed by means of a tunnel as well.
On May 29, 1991 the tunnel was officially opened, along with the Hanover-Fulda part of the high-speed rail line.