The M10 between Livingstone and Kazungula (where there is a narrow border to Botswana) and extending further west to Sesheke (where there is a border to Namibia's Caprivi Strip) is a major route used by motorists for international trade and travelling between Zambian cities and the respective countries of Botswana, Namibia and South Africa.

[4] The M10 road is also on the main route between Botswana and Lusaka (Zambia's capital city) and countries like DR Congo and Malawi.

3 kilometres west of Sesheke, at a junction with the RD325 road, at the point where the Zambezi River stops being a national borderline and turns northwards, the M10 road crosses in a south-westerly direction as the Katima Mulilo Bridge (completed in 2004[5]) to be on the western side of the Zambezi River, before meeting the Namibia (Katima Mulilo) Border Post.

The M10 road crosses back to the eastern side of the Zambezi River as the Sioma Bridge and continues north for 85 kilometres to the town of Senanga, which is near the southern point of the Barotse Floodplain.

From Senanga, the M10 road goes north for 100 km, through the Lui Toll Plaza,[9] to the town of Mongu, which is the capital of the Western Province and Barotseland.

The M10 ends at an intersection with the M9 road from Lusaka at a roundabout in Mongu Central (adjacent to Barotse Shopping Mall).