It is traversed from west to east by the Nizip, Merzimen (Bozatlı), and Sajur rivers.
It is inhabited by a Turkmen density in addition to Arabs and other ethnic minorities.
In the south it is joined by the arid steppe of the northern Syrian Desert.
Irrigation based agriculture has been practiced in the plain since ancient times.
The ancient Zeugma on the Euphrates is found in the northern end of the plain.