The highway connects the city of Selkirk to PTH 59, the main route to Grand Beach and cottage country on the east side of Lake Winnipeg.

The highway heads northeast for a few kilometers to leave Selkirk and enter Rural Municipality of St. Andrews.

[9] At this point, PTH 4 began near the Ontario border, passing through Whitemouth and Beausejour to Lockport.

[10] Eight miles west of the Winnipeg city limits, PTH 4 branched off to the right through St. Francois Xavier and Poplar Point.

[11] In 1968, PTH 4's eastern terminus was returned to its previous location with the Trans-Canada Highway eight miles west of Portage la Prairie.