Marie Curie High School (French: Lycée Marie Curie, Vietnamese: Trường Trung học Phổ thông Marie Curie) is a public high school in District 3, Ho Chi Minh City, Vietnam.

Established in 1918 and named after the Nobel prize-winning scientist Marie Curie by the French colonial government, it remains the sole high school in Saigon that still bears its original name.

In the recent past, it was one of the largest high schools in Vietnam, with around 5000 students in regular attendance.

Lycée Marie Curie School was established between 1858 and 1862 (the year France gained protection of Cochinchina under the Treaty of Nham Tuat).

After the Japanese entered Indochina in 1941, the school was requisitioned as a hospital, so all activities were moved to a kindergarten on Pham Ngoc Thach Street.