Mark Twain is a neighborhood of St. Louis, Missouri named after author and Missouri native Mark Twain.

It is located between Interstate 70 and Bellefontaine Cemetery.

In 2020 Mark Twain's racial makeup was 95.1% Black, 2.4% White, 0.2% Native American, 0.3% Asian, 1.4% Two or More Races, and 0.6% Some Other Race.

1.0% of the population was of Hispanic or Latino origin.

This St. Louis location article is a stub.