[5] One of the oldest communities in the city, Soulard is today a largely residential neighborhood whose many businesses include restaurants, bars, and the North American headquarters of Anheuser-Busch, which houses the St. Louis Brewery.

The neighborhood is divided roughly by Lynch Street; north of which is mostly row homes and small apartments, and south of which is largely the Anheuser-Busch Brewery and headquarters.

The barrelhouse blues piano player James Crutchfield lived in the neighborhood from 1984 until his death in 2001 and performed in many of the nightclubs.

Soulard Market is featured in the opening scene of Alan Schroeder's picture book Ragtime Tumpie.

Soulard hosts many events throughout the year, including celebrations of Mardi Gras and Oktoberfest.