In the portion of the neighborhood north of St. Louis Avenue, dozens of homes have been renovated by individuals and families over the past 25 years.

Along North Market Street and one block to the south along Monroe Avenue, new homes have been built.

A 27 building, $35 million redevelopment of the former 14th Street pedestrian mall was to be built in partnership with Old North St. Louis Restoration Group, a neighborhood association.

Among the neighborhood's landmark structures was the Mullanphy Emigrant Home building, constructed in 1867 using funds from the estate of mayor Bryan Mullanphy to provide temporary shelter and supportive services to the thousands of immigrants who settled in St. Louis during the years after the Civil War.

[3] In the mid 19th century, part of Old North St. Louis was predominantly Irish in population; that section was known as Kerry Patch.