Formerly known as Oak Hill, Tower Grove South is bounded by Arsenal Street on the north, Chippewa Street on the south, Kingshighway Boulevard on the west, and Grand Boulevard on the east.

The majority of the neighborhood was built following the extension of streetcar lines from downtown St. Louis.

During the 1990s through the present, the neighborhood has been reversing a slow decline with the widespread rehabilitation of residential, commercial, and mixed use structures.

The Grand Boulevard business district on the eastern flank of the neighborhood was the first urban business district in the neighborhood to see rehabilitation and new pedestrian scale construction.

After 2000, the smaller Morganford Road business district on the west side of the neighborhood has also seen substantial reinvestment in the form of new restaurants, bars, retail, and a neighborhood scale storefront grocery store, specializing in Natural foods and locally grown foods.