The neighborhood is located on the north side of the city just south of Interstate 70 and west of O’Fallon Park.

[2] Penrose residents are served by the St. Louis Public School District.

[8] Ashland Branch School, originally a receiving home for the Children's Home Society of Missouri, was operated by the district as a preschool and kindergarten until its closure in 2009 and is now listed as under contract as of 2023.

[7][9] The Roman Catholic Archdiocese of St. Louis operates the St. Louis Catholic Academy, a K-8 school, at 4720 Carter Ave.[10] St. Louis Public Library operates the Julia Davis Library at 4415 Natural Bridge Ave.[11] Eugene "Tink" Bradley Park, a 3.18 acre city-run park with a basketball court, softball field, and playground, is located in the neighborhood.

[13] The Roman Catholic Archdiocese of St. Louis operates the St. Elizabeth Mother of John the Baptist Catholic Church at 4330 Shreve Ave.[14] St. Peter A.M.E. Church, a historic African Methodist Episcopal congregation, moved into the neighborhood in 1962 at 4730 Margaretta Ave.[15]