The assumed course of study at Marmaduke is the Smart Core curriculum developed by the Arkansas Department of Education.

Students are engaged in regular and Advanced Placement (AP) coursework and exams prior to graduation, with the opportunity for qualified students to be named honor graduates based on grade point average and additional coursework above minimum requirements.

For 2012–14, the Marmaduke Greyhounds participate in the 2A 3 Conference administered by the Arkansas Activities Association.

The Greyhounds compete in interscholastic competition including golf (boys/girls), basketball (boys/girls), cheer, baseball, softball, and track and field (boys/girls).

Former student Amy Dixon (1995–98) was selected to 5 "All-State" teams (3 softball, 2 basketball), tied for 4th highest in state history.