[9] Santoro most frequently uploads top ten lists, such as "10 Forbidden Places You’re Not Allowed to Visit!"

He tearfully talked about an unnamed romantic partner, who he claimed was manipulative and forced him to turn his friends and family away in favour of her and she had also psychologically and physically abused him during their relationship.

[13] It was claimed by his friend, Rob Gavagan (né Dyke), that the "unnamed partner" mentioned in the video was Nicole Arbour.

[14] Santoro moved to Los Angeles in the first week of January 2017 and possesses a U.S. green card, but maintained his Canadian citizenship.

[23][24] In a tweet published on August 15, 2021, Santoro announced that he was leaving YouTube after 10 years of uploading, in favour of streaming on Twitch.

Those who took part included Rhett and Link, Kanwer Singh, Daym Drops, MatPat, Hank Green, iJustine, and the Fine Brothers.

[30] Santoro, along with Yousef Saleh Erakat, Soledad O'Brien and will.i.am hosted the Global Citizen 2015 Earth Day event.

[31][32] On September 26, 2015, Santoro, along with AsapScience, Stephen Colbert and Hugh Jackman hosted the Global Citizen festival.