The Matupiri Sustainable Development Reserve (Portuguese: Reserva de Desenvolvimento Sustentável do Matupiri) is a sustainable development reserve in the state of Amazonas, Brazil.

[4] It was one of five conservation units created to meet some of the environmental licensing requirements for the work to upgrade the BR-319 highway from Porto Velho to Manaus, which was suspended by Carlos Minc, the Minister of the Environment.

Thus the paving of BR-163 from Cuiabá, Mato Grosso to Santarém, Pará had increased deforestation in the area by 500%.

[6] In December 2012 the Amazonas state government allocated more than R$6 million to these nine units, covering 30,000 square kilometres (12,000 sq mi) and 143 communities, to be coordinated by the State Center for Conservation Units (CEUC).

[6] The management plan for the Matupiri Sustainable Development Reserve was approved on 22 July 2014.