MediaQuest also owns majority interest on newspaper companies The Philippine Star and Business World Publishing Corporation (BusinessWorld), and 30% of film production unit Unitel Group.

In 1998, MediaQuest acquired Nation Broadcasting Corporation from the consortium of the Yabut family and then House Speaker Manny Villar.

In 2007, MediaQuest acquired GV Broadcasting Systems and its owner Satventures Inc., a direct-to-home satellite provider and radio network, from the Galang family.

[3] In 2013, MediaQuest, through subsidiary Hasting Holdings, took over and later acquires the 70% ownership share on newspaper BusinessWorld after contributing to the company's capital.

[5] In May 2022, PLDT named Smart Communications SVP/Head of Consumer Business Jane Basas as new President and CEO of MediaQuest Holdings, replacing Espinosa who remained as board member and retained his positions for Philstar/Hastings and Meralco.

[8][9] On August 10, 2022, ABS-CBN and MediaQuest Holdings signed a "convertible note agreement" as announced on the following day for the ABS-CBN's investment into TV5 Network by acquiring 34.99% of the company's common shares, with an option to increase it stake to 49.92% within the next eight years with MediaQuest remained as the TV5's controlling shareholder with 64.79% of TV5's common shares.

[15] On August 24, the two broadcasting companies agreed to pause their closing preparations for the deal following concerns from politicians and some government agencies.

MQuest was launched in 2023 and is described as the “content creation hub” of the MediaQuest Group “combining film and TV production, talent management, and live events.